{"id":110870,"date":"2026-05-22T13:15:13","date_gmt":"2026-05-22T10:15:13","guid":{"rendered":"https:\/\/prizrenpost.com\/al\/shkencetaret-zbulojne-mekanizmin-e-fshehur-qe-kontrollon-sheqerin-e-depozituar-ne-trup\/"},"modified":"2026-05-22T13:15:13","modified_gmt":"2026-05-22T10:15:13","slug":"shkencetaret-zbulojne-mekanizmin-e-fshehur-qe-kontrollon-sheqerin-e-depozituar-ne-trup","status":"publish","type":"post","link":"https:\/\/prizrenpost.com\/al\/shkencetaret-zbulojne-mekanizmin-e-fshehur-qe-kontrollon-sheqerin-e-depozituar-ne-trup\/","title":{"rendered":"Shkenc\u00ebtar\u00ebt zbulojn\u00eb mekanizmin e fshehur q\u00eb kontrollon sheqerin e depozituar n\u00eb trup"},"content":{"rendered":"
\"Shkenc\u00ebtar\u00ebt<\/figure>\n

Studiuesit kan\u00eb zbuluar nj\u00eb m\u00ebnyr\u00eb t\u00eb panjohur se si trupi rregullon glikogjenin, form\u00ebn e depozituar t\u00eb sheqerit, duke hapur mund\u00ebsi t\u00eb reja p\u00ebr trajtimin e diabetit dhe s\u00ebmundjeve t\u00eb lidhura me t\u00eb<\/p>\n

Studiuesit e Walter and Eliza Hall Institute, WEHI, kan\u00eb zbuluar nj\u00eb proces t\u00eb papritur biologjik q\u00eb mund t\u2019i mund\u00ebsoj\u00eb trupit t\u00eb kontrolloj\u00eb drejtp\u00ebrdrejt sheqerin e depozituar. Ky zbulim sfidon njohurit\u00eb e deritashme mbi biologjin\u00eb dhe mund t\u00eb hap\u00eb drejtime t\u00eb reja p\u00ebr trajtimin e s\u00ebmundjeve q\u00eb lidhen me grumbullimin e tep\u00ebrt t\u00eb sheqerit.<\/p>\n

Studimi, i publikuar n\u00eb revist\u00ebn shkencore Nature, p\u00ebrshkruan nj\u00eb m\u00ebnyr\u00eb t\u00eb mundshme p\u00ebr uljen e drejtp\u00ebrdrejt\u00eb t\u00eb glikogjenit, form\u00ebs n\u00eb t\u00eb cil\u00ebn trupi e ruan sheqerin, kryesisht n\u00eb m\u00ebl\u00e7i dhe muskuj.<\/p>\n

Sipas studiuesve, rezultatet mund t\u00eb ken\u00eb r\u00ebnd\u00ebsi p\u00ebr personat me s\u00ebmundje q\u00eb lidhen me grumbullimin e tep\u00ebrt t\u00eb sheqerit, p\u00ebrfshir\u00eb diabetin, s\u00ebmundjet e zemr\u00ebs dhe disa \u00e7rregullime t\u00eb rralla p\u00ebr t\u00eb cilat ende mungojn\u00eb trajtime efektive.<\/p>\n

\u00c7far\u00eb zbuluan shkenc\u00ebtar\u00ebt<\/p>\n

Shkenc\u00ebtar\u00ebt zbuluan se glikogjeni mund t\u00eb rregullohet drejtp\u00ebrdrejt nga ubiquitin, nj\u00eb protein\u00eb q\u00eb njihet kryesisht p\u00ebr rolin e saj n\u00eb sh\u00ebnimin e proteinave t\u00eb d\u00ebmtuara, n\u00eb m\u00ebnyr\u00eb q\u00eb ato t\u00eb riciklohen ose t\u00eb largohen nga qeliza.<\/p>\n

Ky \u00ebsht\u00eb studimi i par\u00eb q\u00eb tregon se ubiquitin mund t\u00eb rregulloj\u00eb glikogjenin te njer\u00ebzit, duke p\u00ebrmbysur m\u00eb shum\u00eb se pes\u00eb dekada t\u00eb kuptimit klasik t\u00eb k\u00ebtij procesi biologjik.<\/p>\n

Pas konsumimit t\u00eb sheqerit, trupi e shnd\u00ebrron tepric\u00ebn n\u00eb glikogjen. Ky proces \u00ebsht\u00eb studiuar p\u00ebr breza t\u00eb t\u00ebr\u00eb dhe p\u00ebr shum\u00eb koh\u00eb \u00ebsht\u00eb konsideruar si i kuptuar plot\u00ebsisht.<\/p>\n

Prof. David Komander, bashkautor i studimit dhe udh\u00ebheq\u00ebs i Divizionit t\u00eb Sinjalizimit t\u00eb Ubiquitin n\u00eb WEHI, tha se gjetjet e zgjerojn\u00eb n\u00eb m\u00ebnyr\u00eb themelore njohurin\u00eb aktuale p\u00ebr biologjin\u00eb.<\/p>\n

Sipas tij, \u00ebsht\u00eb shum\u00eb e mundshme q\u00eb librat e biologjis\u00eb t\u00eb duhet t\u00eb p\u00ebrdit\u00ebsohen pas k\u00ebtij zbulimi, sepse \u00ebsht\u00eb identifikuar nj\u00eb rrug\u00eb e dyt\u00eb p\u00ebrmes s\u00eb cil\u00ebs glikogjeni mund t\u00eb rregullohet drejtp\u00ebrdrejt, me gjas\u00eb sipas nevoj\u00ebs s\u00eb organizmit, transmeton Telegrafi.<\/p>\n

Pse \u00ebsht\u00eb i r\u00ebnd\u00ebsish\u00ebm glikogjeni<\/p>\n

S\u00ebmundjet e ruajtjes s\u00eb glikogjenit jan\u00eb \u00e7rregullime t\u00eb rralla t\u00eb trash\u00ebguara, n\u00eb t\u00eb cilat trupi nuk arrin ta prodhoj\u00eb ose ta shp\u00ebrb\u00ebj\u00eb si duhet glikogjenin. Shum\u00eb prej k\u00ebtyre s\u00ebmundjeve ende nuk kan\u00eb mund\u00ebsi t\u00eb mira trajtimi.<\/p>\n

Grumbullimi i tep\u00ebrt i glikogjenit lidhet edhe me probleme m\u00eb t\u00eb shpeshta sh\u00ebndet\u00ebsore, si diabeti, obeziteti, s\u00ebmundjet e m\u00ebl\u00e7is\u00eb dhe s\u00ebmundjet e zemr\u00ebs.<\/p>\n

Sipas Prof. Komander, barnat e reja, si Ozempic, po e ndryshojn\u00eb m\u00ebnyr\u00ebn se si kontrollohet sheqeri n\u00eb gjak, por veprojn\u00eb n\u00eb m\u00ebnyr\u00eb t\u00eb t\u00ebrthort\u00eb, p\u00ebrmes rregullimit hormonal. Nd\u00ebrsa pa mund\u00ebsin\u00eb p\u00ebr t\u00eb rregulluar vet\u00eb glikogjenin, \u00ebsht\u00eb e v\u00ebshtir\u00eb t\u00eb luftohet grumbullimi i tij, q\u00eb \u00ebsht\u00eb shkaku baz\u00eb i shum\u00eb s\u00ebmundjeve.<\/p>\n

Roli i papritur i ubiquitin<\/p>\n

Ubiquitin njihet si nj\u00eb molekul\u00eb q\u00eb lidhet me proteinat p\u00ebr t\u00eb ndihmuar qeliz\u00ebn t\u00eb identifikoj\u00eb dhe largoj\u00eb materialin e d\u00ebmtuar. Por glikogjeni nuk \u00ebsht\u00eb protein\u00eb, \u00ebsht\u00eb sheqer.<\/p>\n

Megjithat\u00eb, studiuesit zbuluan se ubiquitin mund t\u00eb lidhet edhe me sheqernat, si n\u00eb modele shtazore, ashtu edhe n\u00eb qelizat njer\u00ebzore.<\/p>\n

Dr. Simon Cobbold, bashkautor i studimit, tha se zbulimi tregon nj\u00eb rol t\u00eb anashkaluar t\u00eb ubiquitin, nj\u00eb molekul\u00eb q\u00eb, sipas tij, ka punuar n\u00eb heshtje n\u00eb sfond p\u00ebr ta mbajtur organizmin gjall\u00eb.<\/p>\n

Zbulimi u mund\u00ebsua fal\u00eb nj\u00eb teknike t\u00eb avancuar t\u00eb quajtur NoPro-clipping, e zhvilluar p\u00ebr kat\u00ebr vjet nga Dr. Cobbold, Prof. Komander dhe autori i par\u00eb i studimit, Marco Jochem.<\/p>\n

Kjo metod\u00eb u lejon shkenc\u00ebtar\u00ebve t\u00eb studiojn\u00eb ubiquitin n\u00eb detaje shum\u00eb m\u00eb t\u00eb m\u00ebdha dhe, p\u00ebr her\u00eb t\u00eb par\u00eb, t\u00eb zbulojn\u00eb ngjarje t\u00eb ubiquitinimit q\u00eb nuk lidhen me proteinat, duke p\u00ebrdorur spektrometrin\u00eb e mas\u00ebs.<\/p>\n

\u00c7far\u00eb ndodh gjat\u00eb agj\u00ebrimit<\/p>\n

N\u00eb nj\u00eb nga gjetjet m\u00eb t\u00eb r\u00ebnd\u00ebsishme, studiuesit p\u00ebrdor\u00ebn NoPro-clipping p\u00ebr t\u00eb par\u00eb se si ubiquitin lidhet me glikogjenin n\u00eb m\u00ebl\u00e7in\u00eb e minjve gjat\u00eb ushqyerjes dhe agj\u00ebrimit.<\/p>\n

Kur minjt\u00eb hyn\u00eb n\u00eb gjendje agj\u00ebrimi dhe kishin nevoj\u00eb p\u00ebr energji, nivelet e glikogjenit ran\u00eb. N\u00eb t\u00eb nj\u00ebjt\u00ebn koh\u00eb, shenjat e ubiquitin u rrit\u00ebn, nd\u00ebrsa glikogjeni po zb\u00ebrthehej.<\/p>\n

Kjo sugjeron se lidhja e ubiquitin me sheqerin mund t\u00eb ndihmoj\u00eb n\u00eb rregullimin e shp\u00ebrb\u00ebrjes s\u00eb glikogjenit.<\/p>\n

Studiuesit gjithashtu treguan se shtimi i sh\u00ebnjimit t\u00eb glikogjenit nga ubiquitin uli nivelet e tij brenda qelizave.<\/p>\n

N\u00ebse k\u00ebto rezultate konfirmohen m\u00eb tej te kafsh\u00ebt dhe njer\u00ebzit, zbulimi mund t\u00eb \u00e7oj\u00eb drejt qasjeve krejt\u00ebsisht t\u00eb reja p\u00ebr trajtimin e s\u00ebmundjeve q\u00eb lidhen me metabolizmin e sheqerit.<\/p>\n

\n

Burimi: mesazhi<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Studiuesit kan\u00eb zbuluar nj\u00eb m\u00ebnyr\u00eb t\u00eb panjohur se si trupi rregullon glikogjenin, form\u00ebn e depozituar t\u00eb sheqerit, duke hapur mund\u00ebsi t\u00eb reja p\u00ebr trajtimin e diabetit dhe s\u00ebmundjeve t\u00eb lidhura me t\u00eb Studiuesit e Walter and Eliza Hall Institute, WEHI, kan\u00eb zbuluar nj\u00eb proces t\u00eb papritur biologjik q\u00eb mund t\u2019i mund\u00ebsoj\u00eb trupit t\u00eb kontrolloj\u00eb drejtp\u00ebrdrejt […]<\/p>\n","protected":false},"author":1,"featured_media":110869,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-110870","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-shendetesi"],"_links":{"self":[{"href":"https:\/\/prizrenpost.com\/al\/wp-json\/wp\/v2\/posts\/110870","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/prizrenpost.com\/al\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/prizrenpost.com\/al\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/prizrenpost.com\/al\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/prizrenpost.com\/al\/wp-json\/wp\/v2\/comments?post=110870"}],"version-history":[{"count":0,"href":"https:\/\/prizrenpost.com\/al\/wp-json\/wp\/v2\/posts\/110870\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/prizrenpost.com\/al\/wp-json\/wp\/v2\/media\/110869"}],"wp:attachment":[{"href":"https:\/\/prizrenpost.com\/al\/wp-json\/wp\/v2\/media?parent=110870"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/prizrenpost.com\/al\/wp-json\/wp\/v2\/categories?post=110870"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/prizrenpost.com\/al\/wp-json\/wp\/v2\/tags?post=110870"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}