{"id":118394,"date":"2026-10-01T16:41:26","date_gmt":"2026-10-01T13:41:26","guid":{"rendered":"https:\/\/prizrenpost.com\/al\/jo-implant-por-dhemb-i-ri-japonezet-po-testojne-injeksionin-qe-synon-rritjen-e-dhembeve\/"},"modified":"2026-10-01T16:41:26","modified_gmt":"2026-10-01T13:41:26","slug":"jo-implant-por-dhemb-i-ri-japonezet-po-testojne-injeksionin-qe-synon-rritjen-e-dhembeve","status":"publish","type":"post","link":"https:\/\/prizrenpost.com\/al\/jo-implant-por-dhemb-i-ri-japonezet-po-testojne-injeksionin-qe-synon-rritjen-e-dhembeve\/","title":{"rendered":"Jo implant, por dh\u00ebmb i ri: Japonez\u00ebt po testojn\u00eb injeksionin q\u00eb synon rritjen e dh\u00ebmb\u00ebve"},"content":{"rendered":"<figure class=\"post-featured-image\"><img decoding=\"async\" src=\"https:\/\/prizrenpost.com\/al\/wp-content\/uploads\/2026\/10\/1530.jpg\" alt=\"Jo implant, por dh\u00ebmb i ri: Japonez\u00ebt po testojn\u00eb injeksionin q\u00eb synon rritjen e dh\u00ebmb\u00ebve\"\/><\/figure>\n<p>Trajtimi \u00ebsht\u00eb ende n\u00eb faza klinike dhe fillimisht synon personat me munges\u00eb kongjenitale t\u00eb dh\u00ebmb\u00ebve<\/p>\n<p>Shkenc\u00ebtar\u00ebt n\u00eb Japoni po zhvillojn\u00eb nj\u00eb ila\u00e7 eksperimental n\u00eb form\u00eb injeksioni q\u00eb synon t\u00eb nxis\u00eb rritjen e dh\u00ebmb\u00ebve t\u00eb rinj te njer\u00ebzit \u2013 nj\u00eb qasje q\u00eb, n\u00ebse rezulton e sigurt dhe efektive, mund t\u00eb ndryshoj\u00eb m\u00ebnyr\u00ebn se si trajtohen disa forma t\u00eb munges\u00ebs s\u00eb dh\u00ebmb\u00ebve.<\/p>\n<p>Trajtimi quhet TRG035 dhe bazohet n\u00eb nj\u00eb antitrup q\u00eb bllokon protein\u00ebn USAG-1, e cila vepron si nj\u00eb lloj \u201cfrene\u201d biologjike n\u00eb zhvillimin e dh\u00ebmb\u00ebve.<\/p>\n<p>N\u00eb vitin 2024, Spitali Universitar i Kiotos, n\u00eb bashk\u00ebpunim me Spitalin Kitano dhe kompanin\u00eb Toregem Biopharma, nisi prov\u00ebn e par\u00eb klinike te njer\u00ebzit. Faza e par\u00eb ka p\u00ebr q\u00ebllim para s\u00eb gjithash t\u00eb vler\u00ebsoj\u00eb sigurin\u00eb dhe doz\u00ebn e p\u00ebrshtatshme, jo t\u00eb d\u00ebshmoj\u00eb ende se ila\u00e7i mund t\u2019u rikthej\u00eb dh\u00ebmb\u00ebt pacient\u00ebve.<\/p>\n<p>A ekziston v\u00ebrtet nj\u00eb \u201cset i tret\u00eb\u201d dh\u00ebmb\u00ebsh?<\/p>\n<p>Njer\u00ebzit normalisht zhvillojn\u00eb dy sete dh\u00ebmb\u00ebsh: dh\u00ebmb\u00ebt e qum\u00ebshtit dhe dh\u00ebmb\u00ebt e p\u00ebrhersh\u00ebm.<\/p>\n<p>Megjithat\u00eb, zhvillimi embrional i dh\u00ebmb\u00ebve \u00ebsht\u00eb m\u00eb kompleks. Studiuesit japonez\u00eb po eksplorojn\u00eb mund\u00ebsin\u00eb q\u00eb disa struktura t\u00eb pazhvilluara dentare t\u00eb mund t\u00eb aktivizohen biologjikisht dhe t\u00eb prodhojn\u00eb dh\u00ebmb\u00eb shtes\u00eb.<\/p>\n<p>Nj\u00eb nga t\u00eb dh\u00ebnat q\u00eb e ka nxitur k\u00ebt\u00eb fush\u00eb k\u00ebrkimi \u00ebsht\u00eb hiperdontia \u2013 gjendja n\u00eb t\u00eb cil\u00ebn disa njer\u00ebz zhvillojn\u00eb m\u00eb shum\u00eb dh\u00ebmb\u00eb se numri normal.<\/p>\n<p>Por ideja se t\u00eb gjith\u00eb njer\u00ebzit kan\u00eb nj\u00eb \u201cset t\u00eb tret\u00eb\u201d t\u00eb plot\u00eb dh\u00ebmb\u00ebsh q\u00eb thjesht fle n\u00eb nofull duhet interpretuar me kujdes. Shkenc\u00ebtar\u00ebt po studiojn\u00eb potencialin biologjik p\u00ebr formimin e dh\u00ebmb\u00ebve t\u00eb rinj, jo nj\u00eb komplet t\u00eb gatsh\u00ebm dh\u00ebmb\u00ebsh q\u00eb pret vet\u00ebm t\u00eb aktivizohet.<\/p>\n<p>N\u00eb qend\u00ebr t\u00eb k\u00ebrkimit \u00ebsht\u00eb proteina USAG-1. Ajo nd\u00ebrhyn n\u00eb rrug\u00ebt biologjike q\u00eb kontrollojn\u00eb zhvillimin e dh\u00ebmb\u00ebve, p\u00ebrfshir\u00eb sinjalizimin BMP.<\/p>\n<p>Ekipi i udh\u00ebhequr nga dr. Katsu Takahashi tregoi n\u00eb eksperimente me kafsh\u00eb se bllokimi i USAG-1 me nj\u00eb antitrup neutralizues mund t\u00eb nxis\u00eb formimin e dh\u00ebmb\u00ebve.<\/p>\n<p>N\u00eb nj\u00eb studim t\u00eb publikuar n\u00eb vitin 2021 n\u00eb revist\u00ebn shkencore Science Advances, administrimi i antitrupit anti-USAG-1 riktheu formimin e dh\u00ebmb\u00ebve te modele minjsh me munges\u00eb kongjenitale t\u00eb tyre dhe nxiti formimin e dh\u00ebmb\u00ebve t\u00eb rinj te disa kafsh\u00eb.<\/p>\n<p>Rezultatet preklinike u zgjeruan m\u00eb pas edhe te kafsh\u00eb t\u00eb tjera, \u00e7ka hapi rrug\u00ebn drejt zhvillimit t\u00eb kandidatit njer\u00ebzor TRG035.<\/p>\n<p>Pse kjo qasje do t\u00eb ishte kaq e r\u00ebnd\u00ebsishme<\/p>\n<p>Sot dh\u00ebmb\u00ebt e munguar z\u00ebvend\u00ebsohen kryesisht me implante, ura ose proteza. K\u00ebto jan\u00eb metoda t\u00eb konsoliduara dhe efektive, por ato e z\u00ebvend\u00ebsojn\u00eb dh\u00ebmbin mekanikisht.<\/p>\n<p>Ideja e TRG035 \u00ebsht\u00eb krejt tjet\u00ebr: n\u00eb vend q\u00eb t\u00eb vendoset nj\u00eb struktur\u00eb artificiale, synohet q\u00eb vet\u00eb organizmi t\u00eb nxitet p\u00ebr t\u00eb formuar nj\u00eb dh\u00ebmb biologjik.<\/p>\n<p>N\u00ebse kjo arrihet te njer\u00ebzit, do t\u00eb p\u00ebrfaq\u00ebsonte nj\u00eb kategori t\u00eb re trajtimi n\u00eb stomatologji.<\/p>\n<p>Megjithat\u00eb, studiuesit nuk po synojn\u00eb fillimisht personat q\u00eb kan\u00eb humbur nj\u00eb dh\u00ebmb nga kariesi apo trauma. Fokusi i par\u00eb \u00ebsht\u00eb mungesa kongjenitale e dh\u00ebmb\u00ebve, sidomos oligodontia, ku nj\u00eb person lind pa gjasht\u00eb ose m\u00eb shum\u00eb dh\u00ebmb\u00eb. Spitali Kitano ka njoftuar se pas faz\u00ebs s\u00eb par\u00eb planifikohej nj\u00eb studim i faz\u00ebs IIa pik\u00ebrisht te k\u00ebta pacient\u00eb.<\/p>\n<p>Edhe pse lajmi ting\u00ebllon revolucionar, trajtimi mbetet eksperimental.<\/p>\n<p>Prova e par\u00eb te njer\u00ebzit u projektua p\u00ebr burra t\u00eb sh\u00ebndetsh\u00ebm nga 30 deri n\u00eb 65 vje\u00e7, me t\u00eb pakt\u00ebn nj\u00eb molar t\u00eb munguar, nd\u00ebrsa objektivi kryesor ishte siguria.<\/p>\n<p>Vet\u00ebm n\u00ebse k\u00ebto faza tregojn\u00eb se ila\u00e7i \u00ebsht\u00eb i sigurt dhe funksionon, mund t\u00eb vazhdohet drejt studimeve m\u00eb t\u00eb m\u00ebdha.<\/p>\n<p>Prandaj, p\u00ebr personat q\u00eb sot kan\u00eb dh\u00ebmb\u00eb t\u00eb munguar, implantet, urat dhe protezat mbeten trajtimet e provuara dhe t\u00eb disponueshme.<\/p>\n<p>Por n\u00ebse bllokimi i USAG-1 funksionon te njer\u00ebzit ashtu si\u00e7 ka funksionuar n\u00eb modelet shtazore, stomatologjia mund t\u00eb fitoj\u00eb di\u00e7ka q\u00eb deri tani ka qen\u00eb pothuajse e paimagjinueshme: jo vet\u00ebm z\u00ebvend\u00ebsimin e nj\u00eb dh\u00ebmbi t\u00eb humbur, por nxitjen e trupit p\u00ebr t\u00eb krijuar nj\u00eb t\u00eb ri.<\/p>\n<hr style=\"margin:30px 0\"\/>\n<p style=\"font-size:13px;color:#666\">Burimi: <strong>mesazhi<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Trajtimi \u00ebsht\u00eb ende n\u00eb faza klinike dhe fillimisht synon personat me munges\u00eb kongjenitale t\u00eb dh\u00ebmb\u00ebve Shkenc\u00ebtar\u00ebt n\u00eb Japoni po zhvillojn\u00eb nj\u00eb ila\u00e7 eksperimental n\u00eb form\u00eb injeksioni q\u00eb synon t\u00eb nxis\u00eb rritjen e dh\u00ebmb\u00ebve t\u00eb rinj te njer\u00ebzit \u2013 nj\u00eb qasje q\u00eb, n\u00ebse rezulton e sigurt dhe efektive, mund t\u00eb ndryshoj\u00eb m\u00ebnyr\u00ebn se si trajtohen disa [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":118393,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-118394","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-shendetesi"],"_links":{"self":[{"href":"https:\/\/prizrenpost.com\/al\/wp-json\/wp\/v2\/posts\/118394","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/prizrenpost.com\/al\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/prizrenpost.com\/al\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/prizrenpost.com\/al\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/prizrenpost.com\/al\/wp-json\/wp\/v2\/comments?post=118394"}],"version-history":[{"count":0,"href":"https:\/\/prizrenpost.com\/al\/wp-json\/wp\/v2\/posts\/118394\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/prizrenpost.com\/al\/wp-json\/wp\/v2\/media\/118393"}],"wp:attachment":[{"href":"https:\/\/prizrenpost.com\/al\/wp-json\/wp\/v2\/media?parent=118394"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/prizrenpost.com\/al\/wp-json\/wp\/v2\/categories?post=118394"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/prizrenpost.com\/al\/wp-json\/wp\/v2\/tags?post=118394"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}