A team of scientists from Philadelphia, USA has created an experimental plant-based chewing gum that aims to reduce the viral load in the mouth by capturing and neutralizing viruses before they spread, according to Science Daily.<\/p>\n
The goal of this product is to reduce the transmission of respiratory viruses through saliva, and is not intended to replace approved vaccines or treatments.<\/p>\n
The gum contains antiviral proteins produced by plants that act locally in the oral cavity.<\/p>\n
One version is enriched with a protein called ACE2, which binds to the “spike” protein of SARS\u2011CoV\u20112 and “captures” viruses in saliva.<\/p>\n
This binding reduces the ability of the virus to enter human cells.<\/p>\n
Laboratory studies have shown that this gum can reduce the viral load of SARS\u2011CoV\u20112 in saliva samples by more than 95%, preventing the virus from entering cells in in vitro tests.<\/p>\n
Researchers are also working on another version of the gum that includes other plant proteins in the formula.<\/p>\n
These proteins bind to the outer structures of viruses, capturing not only SARS\u2011CoV\u20112, but also flu viruses and herpes viruses, in laboratory experiments that have been done so far now.<\/p>\n
These results have been published in the scientific journal Molecular Therapy, but so far have been based mostly on in vitro tests, not large human studies.<\/p>\n
Local action in the mouth: Many viruses are spread through droplets of saliva, so reducing the viral load in saliva can decrease transmission.<\/p>\n
Plant bioengineering: Therapeutic proteins can be produced in plants, making the production more economical and potentially more applicable than traditional methodologies.<\/p>\n
Potential for supplemental use: This product is intended as an adjunct to prevention of spread, not a replacement for recommended vaccines and treatments.<\/p>\n
A clinical trial initiated by the University of Pennsylvania School of Dentistry is now evaluating the safety and effectiveness of SARS\u2011CoV\u20112 neutralizing gum in infected persons.<\/p>\n
Public studies are still in the initial stage, and require further data from human populations before official recommendations for widespread use can be made.<\/p>\n
Research on plant-based antiviral gum is one of the laboratory researches in the clinical trial stage, and shows an innovative approach to reduce the transmission of viruses in saliva.<\/p>\n
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