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A new study shows that the use of slimming drugs such as Ozempic, Wegovy and Mounjaro can increase the risk of osteoporosis by about 30 percent, but experts say that physical activity can reduce this effect. A new study warns that popular slimming drugs, such as Ozempic, Wegovy and Mounjaro, may increase the risk of osteoporosis by around 30 percent. However, experts point out that this risk can be reduced with regular physical activity, especially strength exercises.<\/p>\n
Drugs from the group of GLP-1 receptor agonists have changed the way obesity and type 2 diabetes are treated. But while their effects on weight loss are highly appreciated, researchers are increasingly warning about possible long-term consequences. Scientists, led by dr. John Horneff from the University of Pennsylvania analyzed the medical records of more than 146,000 adults with obesity and type 2 diabetes over a five-year period. They compared patients who used these drugs with those who did not.<\/p>\n
The results showed that users of GLP-1 drugs had about a 30 percent higher risk of developing osteoporosis, a disease that makes bones weaker and more prone to breaking. About 4 percent of users developed this problem, compared to just over 3 percent of nonusers. An increase in cases of osteomalacia, a condition that causes softening of the bones, was also observed.<\/p>\n
Experts point out that the problem is not directly related to the drug alone, but to the rapid weight loss. Any major weight loss is associated with a decrease in bone mineral density. When the weight falls quickly, the mechanical pressure on the bones is also reduced, which normally helps to strengthen and renew them. In addition, up to 40 percent of the weight lost can be fat-free body mass, including muscle, which increases the risk of weakened bones and fractures.<\/p>\n
However, another study published in the journal JAMA Network Open shows that physical activity can help protect bones. People who used these drugs but did not exercise had lower bone density in their hips and spine. While those who combined the medication with regular exercise, especially strength and resistance exercises, managed to maintain better bone health. Doctors therefore recommend that people using these drugs consult with specialists about a food plan rich in protein and calcium, as well as a regular exercise program that helps maintain muscle and bone mass.<\/p>\n
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