![](\"https:\/\/prizrenpost.com\/en\/wp-content\/uploads\/2026\/08\/23.png\")
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Fruthi \u00ebsht\u00eb nj\u00eb infeksion tep\u00ebr ngjit\u00ebs q\u00eb shfaqet me ethe, koll\u00eb dhe pu\u00e7rra n\u00eb l\u00ebkur\u00eb. Pas miratimit t\u00eb vaksin\u00ebs kund\u00ebr fruthit, shytave dhe rubeol\u00ebs (MMR) n\u00eb vitet 1960, p\u00ebrhapja e k\u00ebsaj s\u00ebmundjeje ra ndjesh\u00ebm; madje, n\u00eb vitin 2000, virusi u konsiderua i eliminuar n\u00eb Shtetet e Bashkuara.<\/p>\n
Pavar\u00ebsisht k\u00ebsaj, vitet e fundit jan\u00eb shoq\u00ebruar me ulje t\u00eb nivelit t\u00eb vaksinimit, gj\u00eb q\u00eb ka sjell\u00eb shtim t\u00eb rasteve dhe shp\u00ebrthimeve t\u00eb fruthit n\u00eb t\u00eb gjith\u00eb Shtetet e Bashkuara, por edhe globalisht.<\/p>\n
\u201cKa nj\u00eb num\u00ebr n\u00eb rritje njer\u00ebzish q\u00eb nuk mund t\u00eb vaksinohen ose nuk jan\u00eb vaksinuar plot\u00ebsisht\u201d, tha Erica Ollmann Saphire, biologe strukturore dhe imunologe n\u00eb Institutin La Jolla p\u00ebr Imunologji n\u00eb nj\u00eb njoftim p\u00ebr shtyp. \u201cT\u00eb nj\u00ebjt\u00ebt njer\u00ebz q\u00eb nuk mund t\u00eb vaksinohen ose nuk mund t\u00eb vaksinohen ende, jan\u00eb t\u00eb nj\u00ebjt\u00ebt njer\u00ebz p\u00ebr t\u00eb cil\u00ebt nj\u00eb infeksion nga virusi i fruthit do t\u00eb ishte m\u00eb i r\u00ebndi \u2013 ose vdekjeprur\u00ebs\u201d.<\/p>\n
Sipas revist\u00ebs shkencore \u201cThe Scientist\u201d, kjo e shtyu at\u00eb dhe ekipin e saj t\u00eb hartonin epitopet, pra pjes\u00eb t\u00eb caktuara t\u00eb virusit q\u00eb identifikohen nga antitrupat e nxitur nga vaksina, si edhe t\u00eb gjenin nj\u00eb terapi t\u00eb posa\u00e7me kund\u00ebr fruthit p\u00ebr k\u00ebt\u00eb grup pacient\u00ebsh m\u00eb t\u00eb cenuesh\u00ebm.<\/p>\n
N\u00eb studimin m\u00eb t\u00eb ri, t\u00eb botuar n\u00eb \u201cCell Host & Microbe\u201d, Saphire dhe bashk\u00ebpun\u00ebtor\u00ebt e saj identifikuan nj\u00eb grup antitrupash njer\u00ebzor\u00eb q\u00eb veprojn\u00eb kund\u00ebr virusit t\u00eb fruthit te persona t\u00eb vaksinuar me vaksin\u00ebn MMR. K\u00ebta antitrupa u lidh\u00ebn ose me protein\u00ebn e bashkimit t\u00eb fruthit (F), ose me protein\u00ebn e ngjitjes (H) n\u00eb sip\u00ebrfaqen e virusit, dhe arrit\u00ebn t\u00eb bllokonin infeksionin n\u00eb nj\u00eb model kafsh\u00ebsh. Duke qen\u00eb se studiuesit vun\u00eb re si efekt mbrojt\u00ebs parandalues, ashtu edhe terapeutik, kjo pun\u00eb mund t\u00eb orientoj\u00eb zhvillimin e trajtimeve t\u00eb ardhshme.<\/p>\n
Pjesa m\u00eb e madhe e antitrupave t\u00eb krijuar nga vaksina lidhen me protein\u00ebn H. Megjithat\u00eb, nj\u00eb pjes\u00eb e antitrupave q\u00eb synojn\u00eb protein\u00ebn F rezultojn\u00eb gjithashtu bllokues shum\u00eb t\u00eb fuqish\u00ebm t\u00eb virusit, edhe pse m\u00ebnyra se si nd\u00ebrveprojn\u00eb nuk \u00ebsht\u00eb sqaruar plot\u00ebsisht. N\u00eb nj\u00eb studim t\u00eb m\u00ebhersh\u00ebm, Saphire dhe koleg\u00ebt e saj kishin p\u00ebrdorur mikroskopin\u00eb krio-elektronike p\u00ebr antitrupat kimerik\u00eb mi-njeri q\u00eb synojn\u00eb protein\u00ebn F.<\/p>\n
P\u00ebrmes k\u00ebsaj metode, ekipi arriti t\u00eb shoh\u00eb m\u00eb qart\u00eb m\u00ebnyr\u00ebn se si k\u00ebta antitrupa lidhen me virusin e fruthit. Kur virusi nd\u00ebrvepron me nj\u00eb qeliz\u00eb njer\u00ebzore, ai p\u00ebson nj\u00eb ndryshim forme p\u00ebr t\u2019u bashkuar me veten [me membran\u00ebn e qeliz\u00ebs am\u00eb dhe m\u00eb pas infekton qeliz\u00ebn prit\u00ebse]. Ve\u00e7an\u00ebrisht, kat\u00ebr antitrupa t\u00eb miut synuan konformacione t\u00eb ndryshme t\u00eb protein\u00ebs F: tre prej tyre u lidh\u00ebn me epitope para bashkimit, duke penguar ndryshimin e form\u00ebs dhe, si pasoj\u00eb, duke ndaluar hyrjen e virusit n\u00eb qeliz\u00eb.<\/p>\n
N\u00eb k\u00ebt\u00eb punim t\u00eb ri, studiuesit k\u00ebrkuan t\u00eb kuptonin n\u00ebse i nj\u00ebjti model shfaqej edhe te antitrupat njer\u00ebzor\u00eb. Ata analizuan gjakun e nj\u00eb pacienti t\u00eb vaksinuar m\u00eb par\u00eb dhe izoluan nj\u00eb panel me 52 antitrupa anti-H dhe 46 antitrupa anti-F. M\u00eb pas, me an\u00eb t\u00eb teknikave t\u00eb imazheris\u00eb 3D, hartuan epitopet strukturore n\u00eb k\u00ebto proteina virale dhe m\u00ebnyr\u00ebn si ato nd\u00ebrveprojn\u00eb me antitrupat njer\u00ebzor\u00eb: u identifikuan kat\u00ebr vende kryesore n\u00eb protein\u00ebn H dhe pes\u00eb n\u00eb protein\u00ebn F. Nj\u00ebsoj si n\u00eb studimin e tyre t\u00eb m\u00ebparsh\u00ebm, k\u00ebta antitrupa treguan gjithashtu aft\u00ebsi neutralizuese.<\/p>\n
\u201cNe zbuluam se k\u00ebto antitrupa jan\u00eb jasht\u00ebzakonisht t\u00eb fuqish\u00ebm\u201d, tha n\u00eb nj\u00eb deklarat\u00eb bashkautori i studimit Dawid Zyla, i cili \u00ebsht\u00eb nj\u00eb studiues postdoktoral n\u00eb grupin e Saphire.<\/p>\n
Kur paneli i antitrupave u testua n\u00eb nj\u00eb model paraklinik me miun, studiuesit pan\u00eb se, n\u00ebse administrohej para ekspozimit ndaj fruthit ose brenda 24 deri n\u00eb 48 or\u00ebsh pas infeksionit, ai ulte ngarkes\u00ebn virale deri n\u00eb 500-fish. K\u00ebta antitrupa mbrojt\u00ebs synonin epitope t\u00eb ndryshme dhe jo-konkurruese, \u00e7ka sugjeron se mund t\u00eb p\u00ebrdoren si nj\u00eb trajtim i fuqish\u00ebm p\u00ebr pacient\u00ebt.<\/p>\n
Edhe pse nevojitet pun\u00eb shtes\u00eb p\u00ebr t\u2019i \u00e7uar k\u00ebto njohuri n\u00eb praktik\u00ebn klinike, studiuesit shprehen optimist\u00eb se gjetjet hapin rrug\u00eb t\u00eb reja p\u00ebr nd\u00ebrhyrje profilaktike ose terapeutike kund\u00ebr fruthit.<\/p>\n
Source: prizrenpost<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":" Fruthi \u00ebsht\u00eb nj\u00eb infeksion tep\u00ebr ngjit\u00ebs q\u00eb shfaqet me ethe, koll\u00eb dhe pu\u00e7rra n\u00eb l\u00ebkur\u00eb. Pas miratimit t\u00eb vaksin\u00ebs kund\u00ebr fruthit, shytave dhe rubeol\u00ebs (MMR) n\u00eb vitet 1960, p\u00ebrhapja e k\u00ebsaj s\u00ebmundjeje ra ndjesh\u00ebm; madje, n\u00eb vitin 2000, virusi u konsiderua i eliminuar n\u00eb Shtetet e Bashkuara. Pavar\u00ebsisht k\u00ebsaj, vitet e fundit jan\u00eb shoq\u00ebruar me […]<\/p>\n","protected":false},"author":1,"featured_media":47483,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-47482","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health"],"views":10,"_links":{"self":[{"href":"https:\/\/prizrenpost.com\/en\/wp-json\/wp\/v2\/posts\/47482","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/prizrenpost.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/prizrenpost.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/prizrenpost.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/prizrenpost.com\/en\/wp-json\/wp\/v2\/comments?post=47482"}],"version-history":[{"count":1,"href":"https:\/\/prizrenpost.com\/en\/wp-json\/wp\/v2\/posts\/47482\/revisions"}],"predecessor-version":[{"id":47484,"href":"https:\/\/prizrenpost.com\/en\/wp-json\/wp\/v2\/posts\/47482\/revisions\/47484"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/prizrenpost.com\/en\/wp-json\/wp\/v2\/media\/47483"}],"wp:attachment":[{"href":"https:\/\/prizrenpost.com\/en\/wp-json\/wp\/v2\/media?parent=47482"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/prizrenpost.com\/en\/wp-json\/wp\/v2\/categories?post=47482"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/prizrenpost.com\/en\/wp-json\/wp\/v2\/tags?post=47482"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}