![](\"https:\/\/prizrenpost.com\/tr\/wp-content\/uploads\/2026\/04\/image_10577-Steak-780x439-1.jpg\")
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Alzheimer hastal\u0131\u011f\u0131yla ba\u011flant\u0131l\u0131 belirli bir genetik varyasyon ta\u015f\u0131yan ya\u015fl\u0131 insanlar, et a\u00e7\u0131s\u0131ndan zengin bir diyet yiyerek beyin sa\u011fl\u0131klar\u0131n\u0131 koruyabilirler.<\/p>\n
JAMA Network Open’da yay\u0131nlanan yak\u0131n tarihli bir ara\u015ft\u0131rma, geneti\u011fe dayal\u0131 ki\u015fiselle\u015ftirilmi\u015f diyet \u00f6nerilerinin k\u00fcresel n\u00fcfusun b\u00fcy\u00fck bir b\u00f6l\u00fcm\u00fcnde bili\u015fsel gerilemeyi \u00f6nlemeye yard\u0131mc\u0131 olabilece\u011fini \u00f6ne s\u00fcr\u00fcyor.<\/p>\n
Her insan, ya\u011flar\u0131n ve kolesterol\u00fcn kan dola\u015f\u0131m\u0131nda ta\u015f\u0131nmas\u0131na yard\u0131mc\u0131 olan bir proteinin yap\u0131m\u0131 i\u00e7in talimatlar sa\u011flayan APOE ad\u0131 verilen bir gen ta\u015f\u0131r. Bu genin, e2, e3 ve e4 olarak adland\u0131r\u0131lan, varyantlar olarak bilinen \u00fc\u00e7 ana versiyonu vard\u0131r. Bir ki\u015fi, her bir ebeveynden farkl\u0131 genetik kombinasyonlar olu\u015fturan bir varyant\u0131 miras al\u0131r. Apolipoproteinler, ya\u011flara ba\u011flanan, karaci\u011fer ve beyindeki kolesterol metabolizmas\u0131nda \u00f6nemli bir rol oynayan bir protein ailesidir.<\/p>\n
APOE e4 varyant\u0131, insan\u0131n evrim tarihindeki genin en eski formudur. \u0130lk olarak milyonlarca y\u0131l \u00f6nce, ilk atalar\u0131m\u0131z\u0131n avlanmaya ba\u015flad\u0131\u011f\u0131 ve b\u00fcy\u00fck miktarda et t\u00fcketmeye ba\u015flad\u0131\u011f\u0131 d\u00f6nemde ortaya \u00e7\u0131kt\u0131. Baz\u0131 antropologlar, insan atalar\u0131n\u0131n birka\u00e7 milyon y\u0131l \u00f6nce neredeyse tamam\u0131 etten olu\u015fan diyetler t\u00fckettikleri bir d\u00f6nemden ge\u00e7tiklerini \u00f6ne s\u00fcr\u00fcyor. Bu zaman \u00e7izelgesi, APOE e4 varyant\u0131n\u0131n g\u00f6r\u00fcn\u00fcm\u00fcyle do\u011frudan e\u015fle\u015fiyor.<\/p>\n
Daha yeni varyantlar olan e3 ve e2, insanl\u0131k tarihinde \u00e7ok daha sonra ortaya \u00e7\u0131kt\u0131. \u0130nsan pop\u00fclasyonlar\u0131 sonunda tar\u0131ma y\u00f6neldi ve daha fazla bitki bazl\u0131 g\u0131da t\u00fcketmeye ba\u015flad\u0131. E3 varyant\u0131n\u0131n yakla\u015f\u0131k 200.000 y\u0131l \u00f6nce ortaya \u00e7\u0131kt\u0131\u011f\u0131 ve omnivor beslenmeye adaptasyonu yans\u0131tt\u0131\u011f\u0131 d\u00fc\u015f\u00fcn\u00fcl\u00fcyor. Bug\u00fcn, e3 varyant\u0131 t\u00fcm k\u00fcresel pop\u00fclasyonlarda bulunan en yayg\u0131n formdur.<\/p>\n
Modern zamanlarda APOE e4 varyant\u0131, ge\u00e7 ba\u015flang\u0131\u00e7l\u0131 Alzheimer hastal\u0131\u011f\u0131 i\u00e7in bilinen en g\u00fc\u00e7l\u00fc genetik risk fakt\u00f6r\u00fcd\u00fcr. Bu varyant\u0131n kopyalar\u0131n\u0131 miras alan ki\u015filerin demans geli\u015ftirme \u015fans\u0131, di\u011fer kombinasyonlara sahip olanlara g\u00f6re \u00e7ok daha y\u00fcksektir. Kuzey Avrupa ve Kuzey Amerika’da, e3\/e4 \u200b\u200b\u200b\u200bveya e4\/e4 kombinasyonlar\u0131na sahip bireyler, t\u00fcm Alzheimer vakalar\u0131n\u0131n yakla\u015f\u0131k y\u00fczde 70’ini olu\u015fturmaktad\u0131r.<\/p>\n
Deneyimi geli\u015ftirmek ve reklamlar\u0131 g\u00f6r\u00fcnt\u00fclemek i\u00e7in \u00e7erezleri kullan\u0131r\u0131z (Google AdSense).
\n “Kabul Et” se\u00e7ene\u011fine t\u0131klayarak \u00e7erezlerin a\u015fa\u011f\u0131daki \u015fartlara g\u00f6re kullan\u0131lmas\u0131n\u0131 kabul etmi\u015f olursunuz.
\n Gizlilik Politikas\u0131
\n ve
\n \u00c7erez Politikas\u0131.
\n “Reddet”i t\u0131klayarak gerekli olmayan \u00e7erezleri reddedebilirsiniz.<\/p>\n
Kaynak: prizrenpost<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":" Alzheimer hastal\u0131\u011f\u0131yla ba\u011flant\u0131l\u0131 belirli bir genetik varyasyon ta\u015f\u0131yan ya\u015fl\u0131 insanlar, et a\u00e7\u0131s\u0131ndan zengin bir diyet yiyerek beyin sa\u011fl\u0131klar\u0131n\u0131 koruyabilirler. JAMA Network Open’da yay\u0131nlanan yak\u0131n tarihli bir ara\u015ft\u0131rma, geneti\u011fe dayal\u0131 ki\u015fiselle\u015ftirilmi\u015f diyet \u00f6nerilerinin k\u00fcresel n\u00fcfusun b\u00fcy\u00fck bir b\u00f6l\u00fcm\u00fcnde bili\u015fsel gerilemeyi \u00f6nlemeye yard\u0131mc\u0131 olabilece\u011fini \u00f6ne s\u00fcr\u00fcyor. Her insan, ya\u011flar\u0131n ve kolesterol\u00fcn kan dola\u015f\u0131m\u0131nda ta\u015f\u0131nmas\u0131na yard\u0131mc\u0131 olan bir […]<\/p>\n","protected":false},"author":1,"featured_media":40162,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-40161","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-saglik"],"views":10,"_links":{"self":[{"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/posts\/40161","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/comments?post=40161"}],"version-history":[{"count":1,"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/posts\/40161\/revisions"}],"predecessor-version":[{"id":40163,"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/posts\/40161\/revisions\/40163"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/media\/40162"}],"wp:attachment":[{"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/media?parent=40161"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/categories?post=40161"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/tags?post=40161"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}