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Ara\u015ft\u0131rmac\u0131lar, v\u00fccudun \u015fekerin depolanm\u0131\u015f formu olan glikojeni d\u00fczenlemesinin daha \u00f6nce bilinmeyen bir yolunu ke\u015ffettiler ve bu da diyabet ve ilgili hastal\u0131klar\u0131n tedavisinde yeni olas\u0131l\u0131klar\u0131n \u00f6n\u00fcn\u00fc a\u00e7t\u0131.<\/p>\n
Walter ve Eliza Hall Enstit\u00fcs\u00fc’ndeki (WEHI) ara\u015ft\u0131rmac\u0131lar, v\u00fccudun depolanan \u015fekeri do\u011frudan kontrol etmesini sa\u011flayabilecek beklenmedik bir biyolojik s\u00fcre\u00e7 ke\u015ffettiler. Bu ke\u015fif, mevcut biyoloji bilgisine meydan okuyor ve a\u015f\u0131r\u0131 \u015feker birikimiyle ili\u015fkili hastal\u0131klar\u0131n tedavisinde yeni y\u00f6nler a\u00e7abilir.<\/p>\n
Bilimsel dergi Nature’da yay\u0131nlanan \u00e7al\u0131\u015fma, v\u00fccudun \u015fekeri ba\u015fta karaci\u011fer ve kaslarda depolad\u0131\u011f\u0131 glikojeni do\u011frudan azaltman\u0131n olas\u0131 bir yolunu anlat\u0131yor.<\/p>\n
Ara\u015ft\u0131rmac\u0131lara g\u00f6re sonu\u00e7lar, \u015feker birikimiyle ili\u015fkili hastal\u0131klara sahip ki\u015filer i\u00e7in \u00f6nemli olabilir. \u015feker hastal\u0131\u011f\u0131, kalp hastal\u0131\u011f\u0131 ve etkili tedavisi h\u00e2l\u00e2 bulunmayan baz\u0131 nadir rahats\u0131zl\u0131klar da dahil olmak \u00fczere a\u015f\u0131r\u0131 \u015feker.<\/p>\n
Bilim insanlar\u0131, glikojenin, hasar g\u00f6rm\u00fc\u015f proteinlerin geri d\u00f6n\u00fc\u015ft\u00fcr\u00fclebilmesi veya h\u00fccreden uzakla\u015ft\u0131r\u0131labilmesi i\u00e7in i\u015faretlenmesindeki rol\u00fcyle bilinen bir protein olan ubikuitin taraf\u0131ndan do\u011frudan d\u00fczenlenebilece\u011fini ke\u015ffettiler.<\/p>\n
Bu, ubikuitinin insanlarda glikojeni d\u00fczenleyebildi\u011fini g\u00f6steren ilk \u00e7al\u0131\u015fmad\u0131r ve bu biyolojik s\u00fcrece ili\u015fkin elli y\u0131l\u0131 a\u015fk\u0131n klasik anlay\u0131\u015f\u0131 tersine \u00e7evirir.<\/p>\n
T\u00fcketimden sonra \u015feker, v\u00fccut fazlas\u0131n\u0131 glikojene d\u00f6n\u00fc\u015ft\u00fcr\u00fcr. Bu s\u00fcre\u00e7 nesiller boyunca incelendi ve uzun s\u00fcredir tamamen anla\u015f\u0131ld\u0131\u011f\u0131 d\u00fc\u015f\u00fcn\u00fcl\u00fcyordu.<\/p>\n
Prof. \u00c7al\u0131\u015fman\u0131n ortak yazar\u0131 ve WEHI Ubiquitin Sinyalleme B\u00f6l\u00fcm\u00fc ba\u015fkan\u0131 David Komander, bulgular\u0131n temel olarak mevcut biyoloji bilgisini geni\u015fletti\u011fini s\u00f6yledi.<\/p>\n
Ona g\u00f6re, b\u00fcy\u00fck olas\u0131l\u0131kla biyoloji ders kitaplar\u0131n\u0131n bu ke\u015fiften sonra g\u00fcncellenmesi gerekecek \u00e7\u00fcnk\u00fc glikojenin muhtemelen organizman\u0131n ihtiyac\u0131na g\u00f6re do\u011frudan d\u00fczenlenebilece\u011fi ikinci bir yol belirlendi. Telegraph.<\/p>\n
Glikojen depo hastal\u0131klar\u0131, v\u00fccudun glikojeni d\u00fczg\u00fcn \u015fekilde \u00fcretemedi\u011fi veya par\u00e7alayamad\u0131\u011f\u0131 nadir kal\u0131tsal bozukluklard\u0131r. Bu hastal\u0131klar\u0131n \u00e7o\u011fu hala iyi tedavi se\u00e7eneklerine sahip de\u011fil.<\/p>\n
A\u015f\u0131r\u0131 glikojen birikimi ayn\u0131 zamanda diyabet, obezite, karaci\u011fer hastal\u0131klar\u0131 ve kalp hastal\u0131klar\u0131 gibi daha s\u0131k g\u00f6r\u00fclen sa\u011fl\u0131k sorunlar\u0131yla da ba\u011flant\u0131l\u0131.<\/p>\n
Prof. Commander’a g\u00f6re Ozempic gibi yeni ila\u00e7lar kan \u015fekerinin kontrol edilme \u015feklini de\u011fi\u015ftiriyor, ancak hormonal d\u00fczenleme yoluyla dolayl\u0131 olarak \u00e7al\u0131\u015f\u0131yorlar. Glikojenin kendisini d\u00fczenleme yetene\u011fi olmadan, bir\u00e7ok hastal\u0131\u011f\u0131n temel nedeni olan birikimiyle m\u00fccadele etmek zordur.<\/p>\n
Ubikitin, h\u00fccrenin hasarl\u0131 materyali tan\u0131mlamas\u0131na ve ortadan kald\u0131rmas\u0131na yard\u0131mc\u0131 olmak i\u00e7in proteinlere ba\u011flanan bir molek\u00fcl olarak bilinir. Ancak glikojen protein de\u011fil \u015fekerdir.<\/p>\n
Ancak ara\u015ft\u0131rmac\u0131lar ubikuitinin hem hayvan modellerinde hem de insan h\u00fccrelerinde \u015fekerlere de ba\u011flanabildi\u011fini ke\u015ffetti.<\/p>\n
Dr. Ara\u015ft\u0131rman\u0131n ortak yazar\u0131 Simon Cobbold, ke\u015ffin, organizmay\u0131 canl\u0131 tutmak i\u00e7in arka planda sessizce \u00e7al\u0131\u015ft\u0131\u011f\u0131n\u0131 s\u00f6yledi\u011fi bir molek\u00fcl olan ubikuitinin g\u00f6zden ka\u00e7an bir rol\u00fcne i\u015faret etti\u011fini s\u00f6yledi.<\/p>\n
Ke\u015fif, Dr. Cobbold, Prof. Komutan ve \u00e7al\u0131\u015fman\u0131n ilk yazar\u0131 Marco Jochem taraf\u0131ndan d\u00f6rt y\u0131l boyunca geli\u015ftirilen NoPro-k\u0131rpma ad\u0131 verilen ileri d\u00fczey bir teknik sayesinde m\u00fcmk\u00fcn oldu.<\/p>\n
Bu y\u00f6ntem, bilim adamlar\u0131n\u0131n ubikuitini \u00e7ok daha ayr\u0131nt\u0131l\u0131 bir \u015fekilde incelemesine olanak tan\u0131r ve K\u00fctle spektrometresi kullanarak ilk kez proteinlerle ili\u015fkili olmayan her yerde bulunma olaylar\u0131n\u0131 tespit ettiler.<\/p>\n
En \u00f6nemli bulgulardan birinde ara\u015ft\u0131rmac\u0131lar, ubikuitinin beslenme ve oru\u00e7 s\u0131ras\u0131nda farelerin karaci\u011ferindeki glikojene nas\u0131l ba\u011fland\u0131\u011f\u0131n\u0131 g\u00f6rmek i\u00e7in NoPro k\u0131rpma y\u00f6ntemini kulland\u0131.<\/p>\n
Fareler a\u00e7 duruma girdi\u011finde ve enerjiye ihtiya\u00e7 duydu\u011funda glikojen seviyeleri d\u00fc\u015ft\u00fc. Ayn\u0131 zamanda, glikojen par\u00e7aland\u0131k\u00e7a ubikuitin etiketlemesi de artt\u0131.<\/p>\n
Bu, ubikuitinin \u015fekere ba\u011flanmas\u0131n\u0131n glikojen y\u0131k\u0131m\u0131n\u0131 d\u00fczenlemeye yard\u0131mc\u0131 olabilece\u011fini g\u00f6steriyor.<\/p>\n
Ara\u015ft\u0131rmac\u0131lar ayr\u0131ca ubikuitin taraf\u0131ndan artan glikojen etiketlemesinin h\u00fccreler i\u00e7indeki seviyelerini azaltt\u0131\u011f\u0131n\u0131 da g\u00f6sterdi.<\/p>\n
Bu sonu\u00e7lar hayvanlarda ve insanlarda daha da do\u011frulan\u0131rsa, ke\u015fif tamamen yeni yakla\u015f\u0131mlara yol a\u00e7abilir. \u015feker metabolizmas\u0131yla ilgili hastal\u0131klar\u0131n tedavisi i\u00e7in.<\/p>\n
Kaynak: prizrenpost<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":" Ara\u015ft\u0131rmac\u0131lar, v\u00fccudun \u015fekerin depolanm\u0131\u015f formu olan glikojeni d\u00fczenlemesinin daha \u00f6nce bilinmeyen bir yolunu ke\u015ffettiler ve bu da diyabet ve ilgili hastal\u0131klar\u0131n tedavisinde yeni olas\u0131l\u0131klar\u0131n \u00f6n\u00fcn\u00fc a\u00e7t\u0131. Walter ve Eliza Hall Enstit\u00fcs\u00fc’ndeki (WEHI) ara\u015ft\u0131rmac\u0131lar, v\u00fccudun depolanan \u015fekeri do\u011frudan kontrol etmesini sa\u011flayabilecek beklenmedik bir biyolojik s\u00fcre\u00e7 ke\u015ffettiler. Bu ke\u015fif, mevcut biyoloji bilgisine meydan okuyor ve a\u015f\u0131r\u0131 \u015feker […]<\/p>\n","protected":false},"author":1,"featured_media":47298,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-47297","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-saglik"],"views":15,"_links":{"self":[{"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/posts\/47297","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/comments?post=47297"}],"version-history":[{"count":1,"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/posts\/47297\/revisions"}],"predecessor-version":[{"id":47299,"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/posts\/47297\/revisions\/47299"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/media\/47298"}],"wp:attachment":[{"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/media?parent=47297"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/categories?post=47297"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/tags?post=47297"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}