![](\"https:\/\/prizrenpost.com\/tr\/wp-content\/uploads\/2026\/07\/13-8.jpg\")
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PARTNER 3 \u00e7al\u0131\u015fmas\u0131, d\u00fc\u015f\u00fck cerrahi riski olan hastalarda \u00e7ok benzer uzun vadeli sonu\u00e7lar g\u00f6stermektedir, ancak TAVR’den sonra komplikasyon \u00f6nemli \u00f6l\u00e7\u00fcde daha s\u0131k ortaya \u00e7\u0131km\u0131\u015ft\u0131r.<\/p>\n
Klasik a\u00e7\u0131k kalp ameliyat\u0131na gerek kalmadan kateterle aort kapak replasman\u0131, i\u015flemden yedi y\u0131l sonra bile ameliyatla kar\u015f\u0131la\u015ft\u0131r\u0131labilir dayan\u0131kl\u0131l\u0131k g\u00f6stermi\u015ftir.<\/p>\n
PARTNER 3 \u00e7al\u0131\u015fmas\u0131n\u0131n sonu\u00e7lar\u0131, aort kapa\u011f\u0131nda ciddi semptomatik stenozu olan ve cerrahi riski d\u00fc\u015f\u00fck olan hastalarda, transkateter aort kapa\u011f\u0131n\u0131n de\u011fi\u015ftirildi\u011fini g\u00f6stermektedir. kapak replasman\u0131nda (TAVR) ve cerrahi replasmanda (SAVR) benzer oranlarda yap\u0131sal kapak hasar\u0131, biyoprotez ba\u015far\u0131s\u0131zl\u0131\u011f\u0131 ve tekrar m\u00fcdahale ihtiyac\u0131 vard\u0131.<\/p>\n
Ancak, TAVR’den sonra kapak trombozu \u00f6nemli \u00f6l\u00e7\u00fcde daha s\u0131k kaydedildi.<\/p>\n
Aort darl\u0131\u011f\u0131, aort kapa\u011f\u0131n\u0131n daralmas\u0131 ve kan\u0131n normal ge\u00e7i\u015fini engellemesi durumunda ortaya \u00e7\u0131kar. kalpten v\u00fccudun geri kalan\u0131na kan. Hastal\u0131k \u015fiddetlendi\u011finde ve semptomlara neden oldu\u011funda kapak de\u011fi\u015fimi gerekli olabilir.<\/p>\n
Uzun y\u0131llard\u0131r standart tedavi, aort kapa\u011f\u0131n\u0131n a\u00e7\u0131k kalp ameliyat\u0131 yoluyla cerrahi olarak de\u011fi\u015ftirilmesi olmu\u015ftur.<\/p>\n
TAVR daha az invazif bir alternatif sunmaktad\u0131r. Yeni kapak, g\u00f6\u011fs\u00fcn klasik bir \u015fekilde a\u00e7\u0131lmas\u0131na gerek kalmadan, genellikle bir arterden giren bir kateter yoluyla yerle\u015ftirilir.<\/p>\n
Ba\u015flang\u0131\u00e7ta bu y\u00f6ntem esas olarak y\u00fcksek riskli cerrahi hastalarda kullan\u0131ld\u0131, ancak kullan\u0131m\u0131 d\u00fc\u015f\u00fck riskli hastalar\u0131 da kapsayacak \u015fekilde geni\u015fledi. Telegrafi’nin raporuna g\u00f6re, bu nedenle TAVR kapaklar\u0131n\u0131n uzun \u00f6m\u00fcrl\u00fcl\u00fc\u011f\u00fc ve dayan\u0131kl\u0131l\u0131\u011f\u0131 \u00f6zellikle \u00f6nemli konular haline geldi.<\/p>\n
PARTNER 3, ciddi semptomatik aort kapak stenozu ve d\u00fc\u015f\u00fck cerrahi riski olan 1.000 hastay\u0131 i\u00e7eren randomize bir \u00e7al\u0131\u015fmayd\u0131.<\/p>\n
Kapak dayan\u0131kl\u0131l\u0131\u011f\u0131 analizinde, 495 hastaya SAPIEN 3 kapakla TAVR uyguland\u0131, 453 hastaya ise cerrahi kapak replasman\u0131 uyguland\u0131.<\/p>\n
Kat\u0131l\u0131mc\u0131lar\u0131n ortalama ya\u015f\u0131: yakla\u015f\u0131k 74 y\u0131l. Hastalar yedi y\u0131l boyunca takip edildi ve ekokardiyografik kontroller de dahil olmak \u00fczere kapak fonksiyonlar\u0131 d\u00fczenli olarak de\u011ferlendirildi.<\/p>\n
Yedi y\u0131l sonra neredeyse ayn\u0131 sonu\u00e7lar<\/p>\n
TAVR’li hastalar\u0131n y\u00fczde 7,3’\u00fcnde ve ameliyat edilen hastalar\u0131n y\u00fczde 7,6’s\u0131nda biyoprotezde \u00f6nemli yap\u0131sal hasar kaydedildi.<\/p>\n
Biyoprotezin t\u00fcm nedenlere ba\u011fl\u0131 ba\u015far\u0131s\u0131zl\u0131\u011f\u0131 da benzerdi: TAVR’dan sonra y\u00fczde 6,9 ve sonras\u0131nda y\u00fczde 7,5. ameliyat.<\/p>\n
TAVR hastalar\u0131n\u0131n y\u00fczde 6’s\u0131nda, ameliyat olan hastalar\u0131n ise y\u00fczde 5,5’inde ba\u015fka bir kapak m\u00fcdahalesine ihtiya\u00e7 duyuldu\u011fu kaydedildi.<\/p>\n
Yedi y\u0131l sonra, TAVR ile tedavi edilen hastalar\u0131n y\u00fczde 73,4’\u00fc ve ameliyat olanlar\u0131n y\u00fczde 74,8’i hayattayd\u0131 ve kapak yetmezli\u011fi yoktu. biyoprotez.<\/p>\n
Tromboz, iki y\u00f6ntem aras\u0131ndaki temel fark<\/p>\n
Kapak trombozunda \u00f6nemli bir fark kaydedildi.<\/p>\n
Tromboza ba\u011fl\u0131 kapak fonksiyon bozuklu\u011fu TAVR sonras\u0131 hastalar\u0131n y\u00fczde 5,2’sinde kaydedilirken, ameliyat sonras\u0131 bu oran yaln\u0131zca y\u00fczde 0,9’du.<\/p>\n
TAVR’den sonraki vakalar\u0131n \u00e7o\u011fu ilk \u00fc\u00e7 y\u0131l i\u00e7inde ortaya \u00e7\u0131kt\u0131 ve bir\u00e7o\u011fu kendili\u011finden veya tedavi sonras\u0131nda d\u00fczeldi. Sadece k\u00fc\u00e7\u00fck bir k\u0131sm\u0131 biyoprotezin ba\u015far\u0131s\u0131zl\u0131\u011f\u0131na kadar ilerledi.<\/p>\n
Bu arada, endokardit ile ili\u015fkili sorunlar nadirdi ve her iki grupta da hemen hemen ayn\u0131yd\u0131.<\/p>\n
Yedi y\u0131ll\u0131k sonu\u00e7lar, d\u00fc\u015f\u00fck cerrahi risk alt\u0131ndaki hastalarda TAVR kullan\u0131m\u0131 i\u00e7in cesaret vericidir ancak bu, bu y\u00f6ntemin herkes i\u00e7in otomatik olarak en iyi se\u00e7im oldu\u011fu anlam\u0131na gelmez.<\/p>\n
Ya\u015f, kapak ve damar anatomisi, koroner arterlerin durumu, komorbiditeler ve beklenen ya\u015fam s\u00fcresi, TAVR kullan\u0131m\u0131nda g\u00f6z \u00f6n\u00fcnde bulundurulmas\u0131 gereken fakt\u00f6rler aras\u0131ndad\u0131r. tedavi se\u00e7imi.<\/p>\n
Sonu\u00e7lar ayr\u0131ca, \u00f6zellikle kapak trombozunun erken tespiti i\u00e7in TAVR sonras\u0131nda hastalar\u0131n takip edilmesinin gereklili\u011fini de g\u00f6stermektedir.<\/p>\n
PARTNER 3 \u00e7al\u0131\u015fmas\u0131 hastalar\u0131n\u0131n on y\u0131ll\u0131k takibinin, bu kapak\u00e7\u0131klar\u0131n \u00e7ok uzun vadeli canl\u0131l\u0131\u011f\u0131 hakk\u0131nda daha net cevaplar vermesi beklenmektedir.<\/p>\n
Kaynak: prizrenpost<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":" PARTNER 3 \u00e7al\u0131\u015fmas\u0131, d\u00fc\u015f\u00fck cerrahi riski olan hastalarda \u00e7ok benzer uzun vadeli sonu\u00e7lar g\u00f6stermektedir, ancak TAVR’den sonra komplikasyon \u00f6nemli \u00f6l\u00e7\u00fcde daha s\u0131k ortaya \u00e7\u0131km\u0131\u015ft\u0131r. Klasik a\u00e7\u0131k kalp ameliyat\u0131na gerek kalmadan kateterle aort kapak replasman\u0131, i\u015flemden yedi y\u0131l sonra bile ameliyatla kar\u015f\u0131la\u015ft\u0131r\u0131labilir dayan\u0131kl\u0131l\u0131k g\u00f6stermi\u015ftir. PARTNER 3 \u00e7al\u0131\u015fmas\u0131n\u0131n sonu\u00e7lar\u0131, aort kapa\u011f\u0131nda ciddi semptomatik stenozu olan ve cerrahi […]<\/p>\n","protected":false},"author":1,"featured_media":54571,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-54570","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-saglik"],"views":11,"_links":{"self":[{"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/posts\/54570","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/comments?post=54570"}],"version-history":[{"count":1,"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/posts\/54570\/revisions"}],"predecessor-version":[{"id":54572,"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/posts\/54570\/revisions\/54572"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/media\/54571"}],"wp:attachment":[{"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/media?parent=54570"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/categories?post=54570"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/tags?post=54570"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}