![](\"https:\/\/prizrenpost.com\/tr\/wp-content\/uploads\/2026\/08\/23.png\")
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K\u0131zam\u0131k, ate\u015f, \u00f6ks\u00fcr\u00fck ve deri d\u00f6k\u00fcnt\u00fcleri ile kendini g\u00f6steren olduk\u00e7a bula\u015f\u0131c\u0131 bir enfeksiyondur. 1960’larda k\u0131zam\u0131k, kabakulak ve k\u0131zam\u0131k\u00e7\u0131k (MMR) a\u015f\u0131s\u0131n\u0131n onaylanmas\u0131n\u0131n ard\u0131ndan bu hastal\u0131\u011f\u0131n yayg\u0131nl\u0131\u011f\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde azald\u0131; hatta 2000 y\u0131l\u0131nda vir\u00fcs\u00fcn Amerika Birle\u015fik Devletleri’nde ortadan kald\u0131r\u0131ld\u0131\u011f\u0131 d\u00fc\u015f\u00fcn\u00fcl\u00fcyordu.<\/p>\n
Buna ra\u011fmen son y\u0131llarda a\u015f\u0131lama oranlar\u0131nda bir d\u00fc\u015f\u00fc\u015f ya\u015fand\u0131 ve bu da Amerika Birle\u015fik Devletleri’nde ve ayn\u0131 zamanda d\u00fcnya genelinde k\u0131zam\u0131k vakalar\u0131nda ve salg\u0131nlarda art\u0131\u015fa yol a\u00e7t\u0131.<\/p>\n
Enstit\u00fc’de \u200b\u200byap\u0131sal biyolog ve imm\u00fcnolog olan Erica Ollmann Saphire, “A\u015f\u0131lanamayan veya tam olarak a\u015f\u0131lanmayan giderek artan say\u0131da insan var” dedi. Bir bas\u0131n b\u00fclteninde \u0130mm\u00fcnoloji i\u00e7in La Jolla. “A\u015f\u0131 yap\u0131lamayan veya hen\u00fcz a\u015f\u0131lanamayan ki\u015filer, k\u0131zam\u0131k vir\u00fcs\u00fc enfeksiyonunun en \u015fiddetli veya \u00f6l\u00fcmc\u00fcl olaca\u011f\u0131 ki\u015filerle ayn\u0131 ki\u015filerdir.” “The Scientist” bilimsel dergisine g\u00f6re bu durum, kendisini ve ekibini epitoplar\u0131n, yani a\u015f\u0131n\u0131n neden oldu\u011fu antikorlar taraf\u0131ndan tan\u0131nan vir\u00fcs\u00fcn belirli k\u0131s\u0131mlar\u0131n\u0131n haritas\u0131n\u0131 \u00e7\u0131karmaya ve k\u0131zam\u0131k i\u00e7in spesifik bir tedavi bulmaya y\u00f6neltti. daha savunmas\u0131z hastalardan olu\u015fan bu grup i\u00e7in.<\/p>\n
Cell Host & Microbe’da yay\u0131nlanan son \u00e7al\u0131\u015fmada Saphire ve i\u015fbirlik\u00e7ileri, MMR a\u015f\u0131s\u0131 ile a\u015f\u0131lanan ki\u015filerde k\u0131zam\u0131k vir\u00fcs\u00fcne kar\u015f\u0131 etki eden bir grup insan antikoru tespit etti. Bu antikorlar, vir\u00fcs\u00fcn y\u00fczeyindeki k\u0131zam\u0131k f\u00fczyon proteinine (F) veya yap\u0131\u015fma proteinine (H) ba\u011fland\u0131 ve bir hayvan modelinde enfeksiyonu engellemeyi ba\u015fard\u0131. Ara\u015ft\u0131rmac\u0131lar hem \u00f6nleyici hem de tedavi edici koruyucu etkiler g\u00f6zlemledi\u011finden bu \u00e7al\u0131\u015fma gelecekteki tedavilerin geli\u015ftirilmesine yol g\u00f6sterebilir.<\/p>\n
A\u015f\u0131 taraf\u0131ndan \u00fcretilen antikorlar\u0131n \u00e7o\u011fu H proteinine ba\u011flan\u0131yor. Bununla birlikte, F proteinini hedef alan baz\u0131 antikorlar\u0131n ayn\u0131 zamanda \u00e7ok g\u00fc\u00e7l\u00fc vir\u00fcs engelleyicileri oldu\u011fu ortaya \u00e7\u0131kt\u0131, ancak bunlar\u0131n nas\u0131l etkile\u015fti\u011fi tam olarak anla\u015f\u0131lmad\u0131. Daha \u00f6nceki bir \u00e7al\u0131\u015fmada Saphire ve meslekta\u015flar\u0131, F proteinini hedef alan kimerik mu-insan antikorlar\u0131 i\u00e7in kriyo-elektron mikroskobu kulland\u0131lar.<\/p>\n
Ekip, bu y\u00f6ntem sayesinde bu antikorlar\u0131n k\u0131zam\u0131k vir\u00fcs\u00fcne nas\u0131l ba\u011fland\u0131\u011f\u0131n\u0131 daha net bir \u015fekilde g\u00f6rebildi. Vir\u00fcs bir insan h\u00fccresiyle etkile\u015fime girdi\u011finde \u015fekil de\u011fi\u015fikli\u011fine u\u011frayarak kendisini [konak\u00e7\u0131 h\u00fccre zar\u0131na ba\u011flar ve ard\u0131ndan konak\u00e7\u0131 h\u00fccreyi enfekte eder. \u00d6zellikle d\u00f6rt fare antikoru, F proteininin farkl\u0131 konformasyonlar\u0131n\u0131 hedef ald\u0131: Bunlardan \u00fc\u00e7\u00fc \u00f6n-ekleme epitoplar\u0131na ba\u011flanarak \u015fekil de\u011fi\u015fikli\u011fini \u00f6nledi ve sonu\u00e7 olarak vir\u00fcs\u00fcn h\u00fccreye girmesini durdurdu.<\/p>\n
Bu yeni makalede, ara\u015ft\u0131rmac\u0131lar ayn\u0131 modelin insan antikorlar\u0131nda da meydana gelip gelmedi\u011fini anlamaya \u00e7al\u0131\u015ft\u0131. Daha \u00f6nce a\u015f\u0131lanm\u0131\u015f bir hastan\u0131n kan\u0131n\u0131 analiz ettiler ve 52 anti-H antikoru ve 46 anti-F antikorundan olu\u015fan bir paneli izole ettiler. Daha sonra, 3 boyutlu g\u00f6r\u00fcnt\u00fcleme tekniklerini kullanarak bu viral proteinlerdeki yap\u0131sal epitoplar\u0131 ve bunlar\u0131n insan antikorlar\u0131yla nas\u0131l etkile\u015fime girdi\u011fini haritaland\u0131rd\u0131lar: H proteininde d\u00f6rt, F proteininde ise be\u015f anahtar b\u00f6lge tan\u0131mland\u0131. \u00d6nceki \u00e7al\u0131\u015fmalar\u0131nda oldu\u011fu gibi, bu antikorlar ayn\u0131 zamanda n\u00f6trle\u015ftirme yetene\u011fi de g\u00f6sterdi.<\/p>\n
Saphire’in grubunda doktora sonras\u0131 ara\u015ft\u0131rmac\u0131 olarak g\u00f6rev yapan \u00e7al\u0131\u015fman\u0131n ortak yazar\u0131 Dawid Zyla, “Bu antikorlar\u0131n son derece g\u00fc\u00e7l\u00fc oldu\u011funu bulduk.”<\/p>\n
Antikor paneli klinik \u00f6ncesi bir fare modelinde test edildi\u011finde, ara\u015ft\u0131rmac\u0131lar k\u0131zam\u0131\u011fa maruz kalmadan \u00f6nce veya enfeksiyondan sonraki 24 ila 48 saat i\u00e7inde uyguland\u0131\u011f\u0131nda viral y\u00fck\u00fc 500 kata kadar azaltt\u0131\u011f\u0131n\u0131 g\u00f6rd\u00fc. Bu koruyucu antikorlar farkl\u0131 ve rekabet\u00e7i olmayan epitoplar\u0131 hedef al\u0131yordu ve bu da bunlar\u0131n hastalar i\u00e7in g\u00fc\u00e7l\u00fc bir tedavi olarak kullan\u0131labilece\u011fini g\u00f6steriyordu.<\/p>\n
Bu bilgileri klinik prati\u011fe ta\u015f\u0131mak i\u00e7in daha fazla \u00e7al\u0131\u015fmaya ihtiya\u00e7 duyulmas\u0131na ra\u011fmen, ara\u015ft\u0131rmac\u0131lar bulgular\u0131n k\u0131zam\u0131\u011fa kar\u015f\u0131 profilaktik veya terap\u00f6tik m\u00fcdahaleler i\u00e7in yeni yollar a\u00e7aca\u011f\u0131 konusunda iyimser.<\/p>\n
Kaynak: prizrenpost<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":" K\u0131zam\u0131k, ate\u015f, \u00f6ks\u00fcr\u00fck ve deri d\u00f6k\u00fcnt\u00fcleri ile kendini g\u00f6steren olduk\u00e7a bula\u015f\u0131c\u0131 bir enfeksiyondur. 1960’larda k\u0131zam\u0131k, kabakulak ve k\u0131zam\u0131k\u00e7\u0131k (MMR) a\u015f\u0131s\u0131n\u0131n onaylanmas\u0131n\u0131n ard\u0131ndan bu hastal\u0131\u011f\u0131n yayg\u0131nl\u0131\u011f\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde azald\u0131; hatta 2000 y\u0131l\u0131nda vir\u00fcs\u00fcn Amerika Birle\u015fik Devletleri’nde ortadan kald\u0131r\u0131ld\u0131\u011f\u0131 d\u00fc\u015f\u00fcn\u00fcl\u00fcyordu. Buna ra\u011fmen son y\u0131llarda a\u015f\u0131lama oranlar\u0131nda bir d\u00fc\u015f\u00fc\u015f ya\u015fand\u0131 ve bu da Amerika Birle\u015fik Devletleri’nde ve ayn\u0131 […]<\/p>\n","protected":false},"author":1,"featured_media":56741,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-56740","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-saglik"],"views":10,"_links":{"self":[{"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/posts\/56740","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/comments?post=56740"}],"version-history":[{"count":1,"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/posts\/56740\/revisions"}],"predecessor-version":[{"id":56742,"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/posts\/56740\/revisions\/56742"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/media\/56741"}],"wp:attachment":[{"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/media?parent=56740"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/categories?post=56740"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/prizrenpost.com\/tr\/wp-json\/wp\/v2\/tags?post=56740"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}